• Matthew et al synthesized and carried out SAR

  2023-09-08

  

  Matthew et al. synthesized and carried out SAR studies of imidazo-[1,2-a]-pyrazine as Aurora kinase inhibitors with enhanced kinase selectivity and found that Pam3CSK4 Biotin 39 showed optimal potency on Aurora-A and Aurora-B with IC50 value of 4 nM and 13 nM while on phosphorylation histone H3 (pH

• Another important question concerns the mechanism by which

  2023-09-08

  

  Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi

• Thus a majority of known chemical and physico chemical metho

  2023-09-07

  

  Thus, a majority of known chemical and physico-chemical methods of metallic ions assay has a number of disadvantages, such as a low sensitivity and selectivity, high costs and complexity of the equipment. Therefore, the development of simple cost-effective sensitive methods of quantitative analysis

• Recently dairy proteins obtained from

  2023-09-07

  

  Recently, dairy proteins obtained from whey have received considerable attention for their antioxidant bioactivity (Bayram et al., 2008; Haraguchi et al., 2011; Zhang et al., 2012). Bovine whey proteins (WP) are widely used in various foods for their nutritional, health-promoting, and functional val

• br Funding This study was

  2023-09-07

  

  Funding This study was supported by a grant from the Science and Technology Program of Guangzhou (No. 2014Y2-00181) and the personnel training program of Southern Medical University (No. PY2015N023). Conflict of interest statement Authors’contributions Introduction Chronic cerebral hypo

• The clinical impact of our findings is also

  2023-09-07

  

  The clinical impact of our findings is also supported by our earlier report that the level of 12-LOX expression was correlated with the tumor stage and grade [17], [52] and that overall, 38% of patients demonstrated elevated levels of 12-LOX in prostate cancer tissue compared with their matching nor

• urokinase br Depletion of serum amino acids Currently the on

  2023-09-07

  

  Depletion of serum amino acids Currently, the only anticancer agents that directly target amino urokinase metabolism are bacterial l-asparaginases (from Escherichia coli and Erwinia chrysanthemi), which are FDA-approved for treatment of pediatric and adult ALL. A potential complication of using b

• Nilvadipine br Conflict of interest statement br Introductio

  2023-09-07

  

  Conflict of interest statement Introduction Currently, adenocarcinoma is the most common histological subtype of lung cancer. Activating mutations and translocations with a potential for targeted therapy are reported predominantly in non-smokers. ALK rearrangement is found in less than 5% of u

• An important and well documented pathway involved in cellula

  2023-09-07

  

  An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate

• Activation of AhR is also known to upregulate the expression

  2023-09-07

  

  Activation of AhR is also known to upregulate the expression of AhRR (AhR repressor), an inhibitor protein of AhR [29]. However, the exact mechanism by which AhRR represses AhR signaling is not well understood. The initial study by Mimura and colleagues suggested that AhRR is capable of directly com

• br Results br Discussion The actin cytoskeleton is a

  2023-09-07

  

  Results Discussion The MCB-613 cytoskeleton is a highly attractive target for many bacterial toxins, owing to its role in activation and locomotion of immune cells, secretion of humoral response factors, and maintenance of protective barriers at the cellular (sub-membrane cytoskeleton) and or

• SB742457 Considering the physicochemical stability results

  2023-09-07

  

  Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit

• used the survey Pompe disease is accompanied by the deficien

  2023-09-06

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the used the survey unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in t

• It is increasingly evident that many metabolic genes are

  2023-09-06

  

  It is increasingly evident that many metabolic genes are associated with cancer progression of various tumor cells, including NSCLC. In particular, GLUT1 overexpression has been reported in NSCLC, and correlations between GLUT1 expression and a number of clinical parameters such as gender, smoking s

• A unique finding in this

  2023-09-06

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic FPH1 for substrate, can regulate CREB phosphoryation in the context of Alzheimer's dise

15008 records 222/1001 page Previous Next First page 上5页 221222223224225 下5页 Last page