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In Gallus gallus four FGFRs FGFR have been
2022-06-29
In Gallus gallus, four FGFRs (FGFR1-4) have been identified, along with 13 FGFs (FGF1–4, 8–10, 12, 13, 16, 18–20) (Thisse and Thisse, 2005). FGFRs are tyrosine kinase receptors that contain an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. Th
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br Significance Metabolites present in the extracellular env
2022-06-29
Significance Metabolites present in the extracellular environment can potently modulate cellular phenotypes and potentially serve as therapeutics for various diseases. Ferroptosis is a non-apoptotic cell death process characterized by the generation of toxic lipid reactive oxygen species (ROS). I
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Macroautophagy hereafter referred to as autophagy depends
2022-06-29
Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl
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br Materials methods br Results FAS c AA AG and
2022-06-29
Materials & methods Results FAS c.-671AA, AG and GG genotypes and A and G mln4924 frequencies were similar in both patients with FMF and healthy control groups, and no significant difference was found (P>0.05, Table 1). The frequency of TC genotype in FASLG in the healthy controls was signifi
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We thus asked whether enhanced AEA levels in the
2022-06-28
We thus asked whether enhanced AEA levels in the thapsigargin reduce the level of age-related inflammatory changes and slow down brain ageing. To answer this question we compared the morphology of microglia and level of pro-inflammatory cytokines in the hippocampus of young and old wild-type and FA
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The replenishment time course of already tethered vesicle to
2022-06-28
The replenishment time course of already-tethered vesicle to became release ready, was examined by TIRFM imaging combined with calcium uncaging. By UV-flash photolysis of caged calcium, intracellular calcium concentration raises rapidly and homogenously throughout the cell (Ellis-Davies, 2008). Upon
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br Introduction The period around birth is a risky
2022-06-28
Introduction The period around birth is a risky time for stroke in infants. Ischemic stroke has been diagnosed in about 1/4000 full-term infants (Nelson and Lynch, 2004) and perinatal stroke represents the second most frequent cause of acute seizures in this age group (Levy et al., 1985). Further
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Endotoxin induced pulmonary hypertension is
2022-06-28
Endotoxin induced-pulmonary egfr cancer is a reproducible finding in various animal models Leeper-Woodford et al., 1991, Weitzberg et al., 1993 and is also a feature of human sepsis where it may affect right ventricular function (Vincent, 1998). Mechanisms such as vasoconstriction and leukocyte agg
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br Acknowledgement The authors are grateful for
2022-06-28
Acknowledgement The authors are grateful for financial support provided from specific university research (MSMT No 21-SVV/2018). Introduction Several recent studies have demonstrated that planaria, flatworms notable for their regenerative capabilities, can develop conditioned place preference
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br Materials and methods br Results
2022-06-28
Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the Raltitrexed of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control conditions, t
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It was speculated that could affect the protein translation
2022-06-28
It was speculated that could affect the protein translation or processing in the HCV replication cycle. The viral protein processing was thus investigated, to establish whether the HCV inhibition was determining an increased amount of unprocessed polyprotein, due to a block in the processing, or a
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Table shows the distribution of all
2022-06-28
Table 3 shows the distribution of all studied groups regarding mutation of GSTP1 gene polymorphism in each group. From 15 COPD smoker patients in group (A), 12 (80%) had heterozygous mutation, from 15 COPD non-smoker patients in group (B), 5 (33.3%) had heterozygous mutation, from 10 control subject
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Recent studies on detailed biochemical and structural charac
2022-06-28
Recent studies on detailed biochemical and structural characterization of plant GSNOR plk inhibitor confirmed their similarities to mammalian homologues [16], [17], [18], [19]. Compared to human GSNOR, plant GSNORs exhibit differences in the composition of the anion-binding pocket, which negatively
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Acknowledgment br Main Text From birth to adulthood humans p
2022-06-28
Acknowledgment Main Text From birth to adulthood, humans progressively acquire and maintain a complex microbial ecosystem at various body sites and cavities. Early on, these microorganisms establish a complex relationship with the host, resulting in the modulation of several biological function
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Introduction Molecular imprinting technology is a method
2022-06-28
Introduction Molecular imprinting technology is a method that combines the material chemistry, biochemistry, and polymer chemistry and has the ability to specifically identify target analytes on shape, size and functional groups. Molecular imprinting polymer (MIP) is developed based on molecular im
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