• Induction of DNA double stranded breaks DSBs

  2020-07-28

  

  Induction of DNA double stranded breaks (DSBs) by radiation is considered an effective approach for the treatment of cancer (Jeggo and Lobrich, 2007, McKinnon and Caldecott, 2007). Both radiation and a wide range of anticancer agents act by the induction of DSB in cancer cells, thereby causing cell

• While a complete review of the molecular mechanisms regulati

  2020-07-28

  

  While a complete review of the molecular mechanisms regulating mammalian DGK activities is beyond the scope of this review, other reviews have covered much of this aspect (Shulga et al., 2011a; Topham and Epand, 2009; Tu-Sekine and Raben, 2011). In general, aside from enzyme NSC 319726 levels, this

• DHODH is the only enzyme in the pyrimidine

  2020-07-28

  

  DHODH is the only enzyme in the pyrimidine biosynthesis that is located in the mitochondria rather than the cytosol. Mitochondria are intracellular organelles that are mainly associated with the electron transport chain (ETC) and generation of cellular energy. Mitochondrial bioenergetics plays a sig

• br Conclusion br Competing interests br Authors contribution

  2020-07-28

  

  Conclusion Competing interests Authors\' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number

• The use of angiotensin receptor blockers such as losartan ha

  2020-07-28

  

  The use of angiotensin receptor blockers such as losartan have been shown to be effective in reducing cardiac fibrosis in a variety of models in animals and humans [34], [35], [36]. One limitation of angiotensin receptor blockers is the neuro-humoral negative feedback mechanism that leads to an incr

• NS 1619 br Materials and methods br Results br Discussion

  2020-07-28

  

  Materials and methods Results Discussion In this study, we investigated two novel candidate therapeutics, the related CRM1-inhibiting SINEs KPT-185 and KPT-276, in treatment of NHL. The results showed that KPT-185 induced growth inhibition, cell-cycle arrest, and apoptosis in tumor NS 1619

• br Discussion Using a cut off of CMV TC CMV

  2020-07-28

  

  Discussion Using a cut-off of 0.075% CMV-TC, CMV-TC levels had excellent sensitivity and specificity in assigning CMV infection status in healthy adults (92%, 100%). Our results were comparable to results from a previous study in adults who were healthy, in chronic renal failure or post-renal tra

• br Material and methods br Results br Discussion The observe

  2020-07-28

  

  Material and methods Results Discussion The observed effect of the donor serostatus on the course of CMV reactivations in CMV seropositive patients suggests that in vitro TCD by addition of 20 mg of alemtuzumab to the bag is not 100% effective in fully depleting grafts from T-cells. This im

• CAM is the first small molecule fragment to inhibit the

  2020-07-28

  

  CAM187 is the first small molecule fragment to inhibit the α-β interface of CK2 without also binding in the ATP site. Due to its fragment-like properties, CAM187 Pam2CSK4 room for further development. These developments could lead to drug-like molecules with high potency and selectivity against CK2

• Previously published data showed an interaction of tubulin a

  2020-07-28

  

  Previously published data showed an interaction of α-tubulin and CK1δ [15] that was validated in the present study using SPR (Fig. 1A). The dominant motifs involved in the CK1δ/α-tubulin interface were defined using a peptide library of peptides covering the CK1δ amino 221 2 synthesis sequence (Sup

• By targeting the COX pathway downstream of

  2020-07-27

  

  By targeting the COX-2 pathway downstream of COX-2 inhibition, there is the potential to maintain prostacyclin levels and decrease the risk of toxicities while also improving efficacy. Multiple studies have shown that, via prostaglandin E (EP) receptor EP4, PGE2 induces proliferation and metastatic

• It has been suggested that NHEJ is the initial default

  2020-07-27

  

  It has been suggested, that NHEJ is the initial default pathway for DSB repair and, when NHEJ fails, HR may take over [56], [57]. Thus, the affinity of DNA-PKcs for the crossover region of Holliday junctions could anticipate an unexpected backup mechanism for the down regulation of improper recombin

• Although there is a growing interest in the biological produ

  2020-07-27

  

  Although there is a growing interest in the biological production of xylitol from renewable materials (Albuquerque et al., 2014, Dhar et al., 2016), at present, most of the xylitol is produced on commercial scale by traditional chemical approach that include hydrogenation of pure d-xylose derived fr

• Isogenic or clinical C difficile TcdA B strains

  2020-07-27

  

  Isogenic or clinical C difficile TcdA-B+ strains were able to infect hamsters and mice and induce similar disease symptoms as those caused by TcdA+B+ strains,13, 15, 50, 51, 52 suggesting that TcdB, either independently or together with other bacterial factors, causes intestinal inflammatory disease

• However it is not clear whether CysLTs induce

  2020-07-27

  

  However, it is not clear whether CysLTs induce eosinophilic migration in vitro. Nagy et al. reported that neither leukotriene C4 (LTC4) nor leukotriene D4 (LTD4) caused chemotaxis of eosinophils [5]. However, Spada et al. reported contradictory findings, showing that CysLTs elicit chemotactic activi

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