• Wide inter individual differences in expression or

  2020-07-27

  

  Wide inter-individual differences in JNJ-38877605 or activity of CYP450 contribute to variations in both clearance and efficacy/toxicity of several drugs. Phenotyping measures provide information on the real-time activities of CYP450 and provide clinically relevant information as they reflect the c

• Our phylogenetic and syntenic analyses

  2020-07-27

  

  Our phylogenetic and syntenic analyses offer explicit annotations for orange-spotted grouper CXC chemokine ligands and receptors, involving straightforward identification and determination of their evolutionary relationships. As shown in phylogenetic trees (Fig. 1, Fig. 2), all orange-spotted groupe

• br Nuclear export and the functions of CRM The nuclear

  2020-07-27

  

  Nuclear export and the functions of CRM1 The nuclear envelope provides a compartmentalized intracellular environment for DNA replication, the synthesis of RNA, and production of ribosomes, and, as such, it can regulate cellular biological processes including apoptosis and proliferation. Nucleocyt

• 5-fluorocytosine mg A previous study conducted by our group

  2020-07-27

  

  A previous study conducted by our group demonstrated that bilateral BNST neurotransmission inhibition evoked by local treatment with CoCl2 enhanced the HR increase evoked by restraint stress without affecting the arterial pressure response [14]. Similar effect was observed after BNST treatment with

• Large yellow croaker Larimichthys crocea are widely cultured

  2020-07-27

  

  Large yellow croaker (Larimichthys crocea) are widely cultured in China but have inferior meat texture compared with wild fish. This result results from excess lipid deposition in the muscle, which reduces mechanical strength (Thakur et al., 2003). The liver is the central of lipid metabolism and st

• Glutamate receptor internalization is thought to occur

  2020-07-27

  

  Glutamate receptor internalization is thought to occur through clathrin-mediated endocytosis Beattie et al. 2000, Carroll et al. 1999, Ehlers 2000, Lin et al. 2000, Man et al. 2000, Wang and Linden 2000, a general mechanism for the internalization of proteins from the plasma membrane (Mousavi et al.

• br Results and discussion br Conclusions A

  2020-07-27

  

  Results and discussion Conclusions A total of 3 ambient variables and 6 flow- and temperature-related operating variables were considered to develop Cox regression models for the four transitional statuses and their degree of significance was examined by their hazard ratios. The temperature of

• Saikosaponin A br DUBs in regulation of critical steps in tu

  2020-07-26

  

  DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer Saikosaponin A to (1) migrate and invade from the origin sites through the extracellular matrix (ECM)

• Numerous small molecule CRF receptor antagonists

  2020-07-25

  

  Numerous small molecule CRF receptor antagonists have been reported in the literature. Some representative examples are shown in . In preclinical studies (DMP696), , was found to be efficacious in preclinical behavioral models for anxiety and depression. In an open label clinical trial with (R121

• br Acknowledgements br Introduction Supramolecular collagen

  2020-07-25

  

  Acknowledgements Introduction Supramolecular collagen assemblies are crucial for the mechanical stability of animal bodies (Myllyharju and Kivirikko, 2004). The basic collagen structure is a triple helix of three chains containing multiple Gly-X-X\' repeats; X and X\' are often proline and 4-h

• br Conflicts of interest br Acknowledgements br Introduction

  2020-07-25

  

  Conflicts of interest Acknowledgements Introduction Atherosclerosis is the number one cause of death in the United States and among the leading causes of morbidity and mortality globally [1]. Inflammation is critical in all stages of atherosclerosis from the formation of a plaque in the ves

• br The ubiquitin proteasome system The ubiquitin proteasome

  2020-07-25

  

  The ubiquitin proteasome system The ubiquitin proteasome system (UPS) plays a significant role in the regulation of cell growth and survival, in addition to maintaining cellular homeostasis. By means of the UPS, vorinostat can precisely and temporally degrade approximately 80% of the entire prot

• Previous studies have shown the harmful effects of NEFA on

  2020-07-25

  

  Previous studies have shown the harmful effects of NEFA on ovarian functionality, such as inhibition of bovine granulosa cell survival and proliferation, steroidogenesis, and follicular development and alteration in oocyte development [36,45,46]. Therefore, the higher levels of NEFA found in the fol

• Mild cognitive impairment MCI is a clinical

  2020-07-25

  

  Mild cognitive impairment (MCI) is a clinical transitional stage between normal aging and Alzheimer disease (AD) [1]. Approximate 15–30% MCI patients convert to AD annually. Although many efforts have been taken to prevent the conversion from MCI to AD [2], [3], there are few biomarkers to predict t

• Ultrasound is an acoustic wave with

  2020-07-25

  

  Ultrasound is an acoustic wave with a frequency >20 kHz that needs a medium to propagate [20]. Accompanied by the spread of an ultrasonic wave, a series of alternating cycles of compression and rarefaction emerge in the liquid medium. During the rarefaction cycle, microbubbles are formed because of

15949 records 802/1064 page Previous Next First page 上5页 801802803804805 下5页 Last page