• br Introduction Percutaneous transcatheter device closure of

  2019-06-19

  

  Introduction Percutaneous transcatheter device closure of atrial septal defects (ASD) has become an effective alternative therapy to surgical repair in patients with secundum type ASD. Amplatzer ASD or ventricular septal defect (VSD) occluders were used for the closure of ASDs or VSDs, respective

• br Mega cohort studies Remote

  2019-06-19

  

  Mega-cohort studies Remote monitoring collects a wealth of data from large numbers of patients which are not subject to saturation or overwritten memory counters within any implantable device. These databases provide an opportunity to better understand system function, patient condition, and dise

• The incidences of AF and AT

  2019-06-19

  

  The incidences of AF and AT have been shown to be relatively high after minimally invasive AF surgery [18–20]. Edgerton et al. [18] demonstrated that compound 3k freedom from AF or AT should be assessed by long-term monitoring. Kron et al. [19] showed that 40% of patients could undergo bilateral PV

• Introduction Personalized medicine is the

  2019-06-19

  

  Introduction Personalized medicine is the major goal of translational research in the post-genomic era. Numerous biomarkers have been identified by genomic or proteomic approach that can reclassify the disease Saikosaponin A and predict clinical outcome. However, to define a specific disease pheno

• The strengths of this definition are its simplicity and

  2019-06-19

  

  The strengths of this definition are its simplicity and its usefulness in translating existing data into daily practice. The shortcomings of this definition include the lack of uniform criteria to suggest an impending fracture as well as the variable definitions of spinal cord SCF, murine recombinan

• br Over the past decade global concern about the disproporti

  2019-06-18

  

  Over the past decade, global concern about the disproportionate burden of disease and mortality in low-income countries, especially in sub-Saharan Africa, has led to a substantial influx of funding for research by many donor and research agencies. This investment has energised in-country research;

• By GBD region in the past two decades

  2019-06-18

  

  By GBD region, in the past two decades, the largest increases in incidence of ischaemic stroke were in eastern Europe, central and east Asia, north and sub-Saharan Africa, and the Middle East (figure 1), with the largest increase (22%) noted in the Democratic Republic of Congo. Notably, some of the

• The greater relative importance of

  2019-06-18

  

  The greater relative importance of indirect causes could be a result of successful addressing of direct complications of pregnancy and childbirth, and of a change in risk factors and disease patterns. Indirect causes of death include the effects of pre-existing disorders, such as HIV infection, ment

• In Grabowski and colleagues report that women consistently u

  2019-06-18

  

  In , Grabowski and colleagues report that women consistently using DMPA were at nearly double the risk of acquiring herpes simplex virus type 2 (HSV2) compared with those using no contraception; in a sensitivity analysis limited to those whose main partner had HSV2, the risk increased by six times.

• Desde otra perspectiva tendiente a

  2019-06-18

  

  Desde otra perspectiva, tendiente find more debilitar las tesis de Ardao y de Rojas Mix, ese mismo año de 1998, Vicente Romero reconsideró la influencia sobre Bilbao de Lamennais e hizo gravitar sobre él el sentido suyo de la latinidad. Ese sentido sería el que pone en circulación el comité Latino d

• More than structural haemoglobin variants have been describe

  2019-06-18

  

  More than 900 structural haemoglobin variants have been described. Of these more than 100 show high oxygen affinity [2]. Erythrocytosis caused by Hb Ypsilanti was first described in 1967 [3], and the mutation results in substitution of amino urotensin ii (β99 Asp→Tyr) involved in the stability of t

• In our study acute toxicities were mild and there

  2019-06-18

  

  In our study, acute toxicities were mild, and there were no Grade 3 or above hematologic toxicities. Only one patient (3.2%) had Grade 3 esophagus toxicity and three patients (9.7%) had Grade 3 lung toxicity. Compared with studies that investigated regimens of oxaliplatin and 5-FU/leucovorin, the pr

• Numerous animal studies have demonstrated beyond

  2019-06-18

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

• Several cases of injury to the circumflex artery owing

  2019-06-18

  

  Several cases of injury to the circumflex artery owing to ablation of the lateral mitral isthmus and inside the CS have been reported. The circumflex artery and the CS share a close relationship. Takahashi et al. reported the first case of acute circumflex artery occlusion during CS ablation, which

• Preamble The J wave syndromes JWSs consisting of the Brugada

  2019-06-18

  

  Preamble The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early repolarization syndrome (ERS), have captured the interest of the cardiology apoptosis inducer over the past 2 decades following the identification of BrS as a new clinical entity by Pedro and Josep Brugada in

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