• A variety of studies have compared the expression profiles

  2018-10-24

  

  A variety of studies have compared the expression profiles, pluripotentiality, and genetic and epigenetic stability of hESC and iPSC including lines generated using different strategies, distinct parental somatic cell types, or reprogramming methods (Bock et al., 2011; International Stem Cell Initia

• To determine whether the inhibition of

  2018-10-24

  

  To determine whether the inhibition of RSK and TTK inhibits neovascularization in vivo, we gave mice LL/2 tumor grafts. Both BI-D1870 and AZ3146, used at doses determined to be non-toxic to animals, significantly improved survival, inhibited tumor growth, and decreased vascular density. In contrast,

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We appreciate the expert technical assistance of N. Hayashi, K. Iseki, T. Hashiguchi, W. Ohashi, M. Kawahara, S. Okamoto, and C. Yamada (Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe). We appre

• br Results br Discussion We

  2018-10-24

  

  Results Discussion We report the development of a method to generate and proliferate iCx26GJCs from mouse iPSCs for use as a disease model and in inner-ear cell therapies targeting GJB2-related hearing loss, the most frequent type of hereditary deafness worldwide. Our induction method until da

• thymidylate synthase inhibitors We functionally screened spo

  2018-10-24

  

  We functionally screened spontaneously active CMs for pacemaker properties, revealing that the majority of such thymidylate synthase inhibitors had ventricular- or atrial-like but not nodal-like properties, when APs were elicited from physiological resting potentials (−80 mV). Nav1.5 is the main so

• A complementary study confirms our findings that GATA is nec

  2018-10-24

  

  A complementary study confirms our findings that GATA6 is necessary for phosphodiesterase inhibitors specification as well as the decreased efficiency of β-like cell generation from the GATA6 PSC line (Shi et al., 2017). This other report did have one major discrepancy with our results; they did no

• A nuance of the conventional conditions has been that while

  2018-10-24

  

  A nuance of the conventional conditions has been that while overall amplification of cell number occurs in the cultures, the percentage of the population possessing regenerative capacity (i.e., SSCs) declines over a several-month period (Kanatsu-Shinohara et al., 2003, 2005, 2011; Kubota et al., 200

• Constituting about of all cells in the

  2018-10-24

  

  Constituting about 40% of all cells in the brain, astrocytes have long been classified as mere passive supporting cells that, for example, promote survival and functional synaptic formation of neurons; however, astrocytes are also essential for the phagocytic elimination of synapses, which refines n

• br Summary The information about the integral state of

  2018-10-24

  

  Summary The information about the integral state of the 3DDS and about the changes of its state at any influence can be sufficient for controlling many technological processes. ND-vectors can reflect the changes in the state of the mixtures. In this case, the polymodality of particle size distrib

• The first one consisted of a combination

  2018-10-24

  

  The first one consisted of a combination of a 0.5-mm-thick polyethylene filter at the entrance of the silicon bolometer and a 6-µm-thick multilayer Mylar beam splitter. This optical configuration allowed to perform measurements in the photon lactacystin range from 4 to 40meV. The second configurat

• The transition from the ray

  2018-10-24

  

  The transition from the ray ψ= 0° to the ray ψ= 115–120° was made during loading because it lipoxygenase inhibitor allowed to obtain the greatest plastic strain, compared with other possible radial paths of repeated loading. Intermediate loadings were performed in each rectilinear loading segment up

• alkylation of dna br Introduction Fatal drug overdoses have

  2018-10-24

  

  Introduction Fatal drug overdoses have reached epidemic levels in the United States, increasing 137% from 2000–2014 (Rudd, Aleshire, Zibbell, & Gladden, 2016). Growth in poisoning deaths, around 90% of which are now caused by drugs (Warner, Chen, Makuc, Anderson, & Miniño, 2011), were the most im

• Data from the Substance Abuse

  2018-10-24

  

  Data from the Substance Abuse and Mental Health Services Administration (SAMHSA), the Centers for Disease Control and Prevention (CDC), the U.S. Census Bureau, and the National Longitudinal Study of Adolescent to Adult Health (Add Health) report that non-Hispanic whites in the U.S. typically have a

• This year is a year of extraordinary changes

  2018-10-24

  

  This year 2016 is a year of extraordinary changes for this journal. The – (formerly – ) has been repositioned to be a journal with international projection especially interested in addressing current issues in the frontier of knowledge in the marketing field. In this new cycle, the is fully committ

• br Funding This study was

  2018-10-23

  

  Funding This study was funded by a research grant from the French Ministry of Health (PHRC 2007, P071228) and sponsored by the Département de la Recherche Clinique et du Développement de l\'Assistance Publique–Hôpitaux de Paris. The Inserm unit 1134 and Institut National de la Transfusion Sanguin

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