• Electric fields EFs provide a powerful

  2018-10-22

  

  Electric fields (EFs) provide a powerful signal with which to stimulate and guide migration of many types of cells in vitro, including NSCs (Cao et al., 2013; Feng et al., 2012a; Li et al., 2008; Meng et al., 2011; Yao et al., 2008, 2009; Zhao et al., 2006). Normally, weak EFs in the TCEP may aid i

• In order to enhance osteochondral commitment

  2018-10-22

  

  In order to enhance osteochondral commitment, we performed chondrogenic pre-induction of ATSC/β-TCP constructs. Ectopic bone formation was installed in more than 75% of samples, suggesting that a sufficient degree of determination was reached to obtain about as much new bone as with non-induced BMSC

• br Introduction Currently heart disease

  2018-10-20

  

  Introduction Currently, heart disease is the leading cause of mortality in the industrialized world, partly due to the inability of the heart to regenerate in adults; and also the dietary and life style changes leading to a marked increase in the incidence of type II diabetes (for review, see Arm

• The following are the supplementary data related to

  2018-10-20

  

  The following are the supplementary data related to this article. Conflict-of-interest disclosure Acknowledgments The authors would like to thank Ms. Kathleen Makielski for proofreading the manuscript. This work was supported by National Natural Science Foundation of China (grant number 81372

• ibmx br Materials and methods br Results br Discussion

  2018-10-20

  

  Materials and methods Results Discussion Conclusion Author contributions Acknowledgments This study was supported by a grant from the Innovative Research Institute for Cell Therapy (A062260) and supported by the a grant of the Korea Health Technology R&D Project through the Korea H

• I-BET-762 cost There was a decrease of NF B nuclear transloc

  2018-10-20

  

  There was a decrease of NF-κB nuclear translocation on immunofluorescence of lung tissue at 4h, in hMSC treated pigs versus untreated controls. The number of I-BET-762 cost with positively staining nuclei for NF-κB was significantly lower in the treatment group compared to controls. This suggests th

• solution dilution calculator br Author disclosure statement

  2018-10-20

  

  Author disclosure statement Acknowledgements Authors would like to thank Dr. T. Ramakrishna Murti for his valuable comments and linguistic corrections in the manuscript. Authors would also like to thank D.I Biotech (Seoul, Korea) for support to analyze neurite outgrowth. This work was supporte

• The host immune response has

  2018-10-20

  

  The host immune response has been identified as a critical regulator of tumor development and progression (Dunn et al., 2004; Fridman et al., 2013; Hadrup et al., 2013). Several types of immune MM-102 participate in immunosurveillance by direct killing or production of cytokines. Our expression pro

• Although the central nervous system is relatively immunotole

  2018-10-20

  

  Although the central nervous system is relatively immunotolerant (Barker and Billingham, 1977) and human fetus-derived NS/PCs and hESC-derived NS/PCs (hESC-NS/PCs) showed weak immunogenicity (Odeberg et al., 2005; Åkesson et al., 2009; Liu et al., 2013a), no studies to date have investigated the ext

• Further support for the hierarchical two

  2018-10-20

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• Primary human fibroblast cultures were

  2018-10-20

  

  Primary human fibroblast cultures were obtained from skin biopsies of FTD patients after informed consent; control iPSCs were generated from BJ fibroblasts. Human iPSC lines were generated and characterized as previously described (Takahashi et al., 2007b). hESC and iPSC lines were differentiated to

• TH-302 Our study shows that iPSCs are highly proficient in a

  2018-10-20

  

  Our study shows that iPSCs are highly proficient in antioxidant defense, which is presumably responsible for the low frequency of oxidative DNA lesions in both the mitochondrial and nuclear genome. Notably, previous non-quantitative proteomic studies revealed an abundant expression of antioxidant en

• Alternative approaches to LV are non viral vectors

  2018-10-20

  

  Alternative approaches to LV are non-viral vectors such as RNA or DNA, which are considered safer due to their integration-free nature (Hardee et al., 2017). However, manufacturing RNA is expensive and difficult because RNA has a propensity to degrade (Yin et al., 2014). On the other hand, DNA plasm

• melanocortin receptor To trace host to graft connectivity of

  2018-10-20

  

  To trace host-to-graft connectivity of transplanted hESC-derived neurons, we next generated hESC lines that stably expressed the tracing and control constructs (Figures 2A and S2A). The engineered hESCs were differentiated using a protocol that results in a high yield of authentic and functional ven

• To determine whether the inhibition of RSK and

  2018-10-20

  

  To determine whether the inhibition of RSK and TTK inhibits neovascularization in vivo, we gave mice LL/2 tumor grafts. Both BI-D1870 and AZ3146, used at doses determined to be non-toxic to animals, significantly improved survival, inhibited tumor growth, and decreased vascular density. In contrast,

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