• We also observed this inside out layering again when

  2018-11-08

  

  We also observed this inside-out layering again when we stained for nestin and MAP2, with strong nestin staining on the cells and processes growing at the outer 75μM of the SFEB (Fig. 2C), an observation we have made with Tuj1 staining as well (Fig. 1E). Within our SFEBs, nestin expression decreased

• Ro 3306 We used the VP transactivation

  2018-11-08

  

  We used the VP64 transactivation domain to generate dTF activators. VP64 at the Oct4 distal enhancer would presumably recruit and interact with histone acetyltransferase p300 and transcriptional activation complexes (Ito et al., 2000; Milbradt et al., 2011) and induce epigenetic changes that facilit

• In hematological malignancies cancer initiating cells have b

  2018-11-08

  

  In hematological malignancies, cancer-initiating order Rimonabant have been identified as a population potentially representing a key clinical target (Matsui et al., 2004; Dick and Lapidot, 2005; Gupta et al., 2009). This paradigm, now extended to some solid cancers, is based on the concept that a

• br Results br Discussion Graft failure

  2018-11-08

  

  Results Discussion Graft failure and rejection for patients with acquired SAA remains as one of the important and life-threatening complications, especially in haplo-HSCT (Wagner et al., 1996; Passweg et al., 2006). The EBMT showed that for patients receiving HLA-identical sibling grafts, the

• br Methods br Results br Discussion

  2018-11-08

  

  Methods Results Discussion The results demonstrate that O2 partial pressure influences SPCs mobilization with repetitive treatments. Whether this is due to augmented NOS-3 activation requires additional study. SPCs mobilization in response to a variety of drugs is compromised by older age,

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion Genotoxic stress and DNA damage are considered to be major causes of aging in mammals. The risk of mutation load and loss of genome integrity in adult stem cells has been proposed to be the principal cause of age related decline in tissue function (R

• br Therapeutic potential of stem cell replacement therapies

  2018-11-08

  

  Therapeutic potential of stem cell replacement therapies Conclusions Author contributions Introduction Intercellular adhesion plays important role in tissue architecture and morphogenesis by controlling the assembly of individual yellow into the three-dimensional tissues (Cavallaro and D

• br Discussion In this study we obtained proof

  2018-11-08

  

  Discussion In this study, we obtained proof-of-concept data to support our hypothesis that AM can rescue OPC differentiation into mature oligodendrocytes under pathological conditions. Our pharmacological approaches also showed that the AM receptor and PI3K/Akt would mediate these AM effects. AM

• SAMHD emerges as a ubiquitous and potent barrier to

  2018-11-08

  

  SAMHD1 emerges as a ubiquitous and potent barrier to productive HIV-1 infection in DCs, myeloid cells, and resting CD4+ T cells. Thus, it appeared likely that SAMHD1 might also be effective when transducing HSPCs with lentiviral vectors. Efficient transduction of HSPCs requires prestimulation with

• Although it is possible that reduced

  2018-11-08

  

  Although it is possible that reduced shear stresses in the injured colon may have favoured HPC7 adhesion, this study suggests that active adhesive mechanisms, similar to those utilised by inflammatory neutrophils, were actually involved in mediating their recruitment. There has been much recent disc

• br Resource table br Resource details Urine

  2018-11-08

  

  Resource table Resource details Urine epithelial cells underwent the reprogramming procedure using the CytoTune®-iPS 2.0 Sendai Reprogramming Kit (Thermo Fisher Scientific, USA) containing reprogramming vectors with the four Yamanaka factors, Oct3/4, Sox2, Klf4 and c-Myc. These factors have be

• This study was approved by

  2018-11-08

  

  This study was approved by the Institutional Stem Cell Research Oversight (ISCRO) committee in the Johns Hopkins University. Blood CD34+ hematopoietic stem cells were obtained with an informed consent from the patient. Materials and methods Acknowledgments We thank the patient for providing b

• br Results br Discussion Here by comparing the WT

  2018-11-08

  

  Results Discussion Here, by comparing the WT CSCs with normal kidney development, we discover two surprising fundamental concepts. First, in terms of lineage hierarchy, the CSC may not correspond to the earliest normal stem cell but rather to a more differentiated progeny. Second, heterogeneit

• Cip Kip proteins are expressed

  2018-11-08

  

  Cip/Kip proteins are expressed at higher levels in HSCs than in progenitor cells (Passegué et al., 2005). The role of p21Cip1 in HSCs is restricted to cell cycle regulation under stress conditions (van Os et al., 2007). p27Kip1 deficiency does not affect HSC numbers or HSC self-renewal, but alters t

• br Funding This work was funded by NIHR GM

  2018-11-08

  

  Funding This work was funded by NIHR01GM085456 awarded to Tanja Dominko. Declaration of interest The following are the supplementary data related to this article. Acknowledgements Introduction The identification of culture conditions that promote the expansion of primitive hematopoieti

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