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We find that the interaction
2025-03-01
We find that the interaction of NSF and SNAP is critically involved in NMDAR-induced PICK1 unclustering. The binding of SNAP to NSF increases the ATPase activity of NSF, which is known to be essential for the unbinding of PICK1 from GluR2 (Hanley et al., 2002). Disruption of the association between
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br Acknowledgments The authors thank
2025-03-01
Acknowledgments The authors thank Claudia Wittrock for her excellent technical assistance. The work was supported by grants of the Deutsche Forschungsgemeinschaft (SFB974 TP B05) and of the Anton-Betz-Stiftung to N.K. A.M. is an associate member of the iBrain graduate school at the University of
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A characteristic of iron present in
2025-03-01
A characteristic of iron present in brain fluids is considerable differences between measured values of ferritin and transferrin and the total iron content value (Table 1). Variation of the latter is compatible with differences in individual metabolisms. However differences between total iron conten
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br Materials and Methods br Results br Discussion
2025-03-01
Materials and Methods Results Discussion Voluminous literature is available describing the regulation of Cy7 NHS ester homeostasis by central and peripheral mechanisms in poultry [35,36]. However, the neuroendocrine mechanism(s) of photoperiod induced hypothalamic regulation of food intake
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In previous research we determined that blocking mAC during
2025-03-01
In previous research, we determined that blocking mAC during heparin-induced capacitation result in sperm having a lesser oxygen consumption, suggesting that cAMP produced by this enzyme would be linked to mitochondrial activity and, therefore, with the regulation of sperm metabolism (Fernández and
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In summary this study reveals that the stability of rapsyn
2025-03-01
In summary, this study reveals that the stability of rapsyn is critically dependent on HSP90β, highlighting a novel function of HSP90β in NMJ formation and maintenance. It also identifies a mechanism in agrin signaling for AChR clustering, i.e., by upregulating the interaction between HSP90β and rap
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Specifically equity injections in a multinational affiliate
2025-03-01
Specifically, equity injections in a multinational affiliate X located in an ACE country can be passed on as lending to another group member Y located in a different country with a high corporate income tax rate. For the group member Y, the interest on the loans is tax deductible, and at the same ti
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br Role of LPA in
2025-02-28
Role of LPA in tumor angiogenesis and skeletal metastasis The angiogenesis switch is essential for tumor expansion and escape of tumor ache inhibitor from the primary site and forming distant metastases. Evidence for the role of LPA2 and LPA3 in the mobility of endothelial cells and the formatio
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Many reports have well documented that signaling pathways pl
2025-02-28
Many reports have well documented that signaling pathways play a pivotal role in controlling longevity. The most studied of these pathways is the IGF-1 pathway [11,12]. A disruption of this pathway has been found to extend longevity in different groups of species starting from Caenorhabditis elegans
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The compounds containing beryllium act as strong Lewis acids
2025-02-28
The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be PF-06463922 []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely strong bidentate B
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Recent progress has been made in translating animal findings
2025-02-28
Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati
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Introduction Preeclampsia a serious hypertensive
2025-02-28
Introduction Preeclampsia, a serious hypertensive disorder that can occur during pregnancy, is a pregnancy-related disease characterized by the onset of ccr5 inhibitor and proteinuria after the 20 t h week of gestation, and it occurs in about 5% of all pregnancies [1]. If left untreated, preeclamp
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Iohexol br Results br Discussion Control of
2025-02-28
Results Discussion Control of chronic inflammation is important in several inflammatory conditions like asthma, rheumatoid arthritis and fibrosis in lung diseases. The regulatory pathways that control chronic inflammation are complex and multi-factorial. Over expression of inflammatory mediato
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In order to further explore whether
2025-02-28
In order to further explore whether the cytoprotective effect of isogarcinol against oxidative stress in H2O2-induced HepG2 Torin1 is a consequence of the breakdown of the endogenous antioxidant defence mechanism, we measured the LDH release, MDA levels, GSH levels and SOD activity. A large body of
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During the course of angiogenesis
2025-02-28
During the course of angiogenesis, the overactivated angiogenic stimulators are responsible for carrying out abnormal proliferation in the retinal microvasculature, resulting in the formation of various immature blood vessels. These newly formed blood vessels become the prime spots for leakage of th