• Enolase as a plasminogen receptor and activator localized on

  2021-04-25

  

  Enolase, as a plasminogen receptor and activator localized on the surface of several helminths, can interact with the host fibrinolytic system (Yang et al., 2010, Du et al., 2009, de la Torre-Escudero et al., 2010). The enzyme is also one of excretory/secretory (ES) products in some helminths, such

• Enhanced responses to varying concentrations of bronchoconst

  2021-04-25

  

  Enhanced responses to varying concentrations of bronchoconstrictors, such as MCh, and airway obstruction are characteristic of YC 1 and common to other clinical states, including chronic obstructive pulmonary disease, lung transplantation, and infection- or chemical agent-induced airway inflammation

• br Materials and methods br Results br Discussion

  2021-04-25

  

  Materials and methods Results Discussion Oxidative stress is a disturbance in the balance of pro- and antioxidant species, resulting in oxidative damage to membrane proteins, lipids, and DNA. Oxidative stress is a predisposing factor for the progression of metabolic diseases and liver injur

• cGAS has a central role

  2021-04-25

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• br Experimental Procedures DNA synthesis

  2021-04-25

  

  Experimental Procedures DNA synthesis reagents were purchased from Glen Research (Sterling, VA). A solution of 0.1 M triethylamine acetate (TEAA) (pH 6.5) was used as HPLC buffer A, and HPLC-grade acetonitrile from Oceanpak (Sweden) was used as HPLC buffer B. All other chemicals were obtained fro

• br Use of recombinant collagen to

  2021-04-23

  

  Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to

• We further evaluated the functional relation between promote

  2021-04-23

  

  We further evaluated the functional relation between promoter regulation of the tumor suppressor genes and in fresh frozen, microdissected tumor tissue from 55 patient with clear cell renal carcinoma. In addition, normal-appearing tissue from the same patient taken distal of the tumor and later hi

• To assess which export pathway

  2021-04-23

  

  To assess which export pathway is used by the iNOS mRNA, we inhibited CRM1 activity by incubation of DLD-1 Actinonin with LMB. Since LMB covalently and exclusively binds to CRM1, it represents a potent and specific inhibitor of the CRM1 transport activity [38]. Inhibition of CRM1 activity as well a

• The identification of CRF receptor subtypes has led to a

  2021-04-23

  

  The identification of CRF Thymidine subtypes has led to a number of studies addressing its functional properties. This paper examines the evidence for CRF1 and CRF2 mediation of fear and anxiety. Recent reviews discussing specific CRF receptor functions associated with other conditions including ea

• The current study showed that the tested nonselective COX in

  2021-04-23

  

  The current study showed that the tested nonselective COX inhibitors potentiated the neuronal (EFS) and endothelial (ACh)-dependent relaxation of rat corpus cavernosum. Indomethacin was the most effective among them in potentiating EFS-induced relaxation. Diclofenac was the most effective in potenti

• Though limited to a large cohort of self reported healthy

  2021-04-23

  

  Though limited to a large cohort of self-reported healthy individuals, associations between individual levosimendan receptor have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-predicted

• Not all of the biological activities exhibited by progestoge

  2021-04-23

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the 3,3',5'-Triiodo-L-thyronine is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the

• br Membrane receptor Indirect non genomic

  2021-04-23

  

  Membrane receptor: Indirect non-genomic signaling As mentioned above, not all pramiracetam australia responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could

• ERRGO mice exhibited increased oxygen consumption decreased

  2021-04-23

  

  ERRGO mice exhibited increased oxygen consumption, decreased RER, high running endurance, and resistance to diet-induced weight gain. These changes are physiological hallmarks of increased aerobic capacity in mice and are a direct consequence of engineering highly oxidative and vascularized muscle b

• By using live imaging of an ERK fluorescence resonance

  2021-04-23

  

  By using live imaging of an ERK fluorescence resonance energy transfer (FRET) sensor, the authors show that ERK activity propagates in a stepwise manner from the center to the periphery of the tracheal placode. This row-by-row propagation of ERK activity fits a relay model in which each row activat

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