• The importance of the microenvironment for

  2019-06-15

  

  The importance of the microenvironment for cancer development and progression is now widely recognised, but it is worth reminding ourselves that this is a relatively young area of research. Anyone searching PubMed today using the terms “” will find over 22,000 scientific publications, with around 30

• Most forms of AVNRT are created by reentry between two

  2019-06-15

  

  Most forms of AVNRT are created by reentry between two (or more) atrial connections to the AV node. The fast AV nodal pathway (shortest conduction time) is formed by transitional cells crossing the tendon of Todaro superiorly. Two slow AV nodal pathways are formed by the rightward and leftward infer

• Si al hablar de realismo se alude en verdad

  2019-06-15

  

  Si al hablar de “realismo” se alude en verdad bms-536924 un determinado tipo de relación entre literatura y realidad, es la pregunta acerca de las características de esta relación la que nos conduce nuevamente a las crónicas de Indias en la medida en que el siglo xvi en Occidente es un momento en el

• African leaders are gathering in Addis Ababa Ethiopia

  2019-06-14

  

  African leaders are gathering in Addis Ababa, Ethiopia, this week for the first ever . The event brings together government officials, including minsters of finance, technical experts, and policymakers, with the goal of advancing the coverage of life-saving immunisations across the continent. In

• br Growth supportive characteristics of the BM vascular nich

  2019-06-14

  

  Growth-supportive characteristics of the BM vascular niche Similar to normal tissues, tumours also need functional blood vessels to support their growth via the delivery of oxygen and nutrients. When a DTC starts proliferating into a micrometastasis, it drives angiogenesis to build new blood vess

• Era tal el recelo que hab a

  2019-06-14

  

  Era tal el recelo que había sobre el enriquecimiento de los ministros que en enero de 1622 se intentó investigar los orígenes de su riqueza. El mismo mes se publicó un decreto que estipulaba que todos los que habían tenido cargos parp inhibitors partir de 1592 debían inventariar sus propiedades ante

• El cap tulo sobre de Jos

  2019-06-14

  

  El capítulo sobre de José Agustín expone las diferencias entre el de Agustín, de 1966, y el de Pacheco, de 1972. Lo que tienen en común ambas obras, aclara el crítico, es que —a diferencia de otras estudiadas en el volumen— no atestiguan momentos de crisis sino “los largos entretiempos que preceden

• Stroke is second only to

  2019-06-14

  

  Stroke is second only to ischaemic mst1 kinase disease as the leading cause of death worldwide; one in six people will have a stroke in their lifetime. , on October 29, reminds us of these striking facts and the need for individuals to know the risk factors. Although the main risk factors for strok

• Ideally assessment of obstetric interventions and outcomes s

  2019-06-14

  

  Ideally, assessment of obstetric interventions and outcomes should be based on high-quality, recent data from the entire population or a representative sample. A key feature of the Robson classification is that it uses information that is available at the onset of labour or delivery, is routinely co

• En una clara cr tica al modelo neoliberal gay importado

  2019-06-14

  

  En una clara crítica al modelo neoliberal gay importado de Estados Unidos, Néstor Perlongher sostiene que “el gay pasa MK-2206 manufacturer tomarse como modelo de conducta. Este operativo de normalización arroja a los bordes a los nuevos marginados, los excluidos de la fiesta: travestis, locas, chon

• When the analysis was matching with propensity

  2019-06-14

  

  When the analysis was matching with propensity score, OS was still significantly longer in JAK2+ patients (median not reached versus 73 months, p=.031) whereas JAK2 status had no significant prognostic value for OS in IPSS intermediate-2 and high patients (p=.18). Discussion In this series, whic

• Involvement of the ventricular myocardium can lead to delaye

  2019-06-13

  

  Involvement of the ventricular myocardium can lead to delayed conduction or anatomical obstacles that are labile to ventricular tachyarrhythmia. Arrhythmias are independently predictive of sudden cardiac death (SCD) [9]. SCD is common in patients with cardiac AL amyloidosis, and prophylactic implant

• According to Weitzman classification patients had

  2019-06-13

  

  According to Weitzman classification [43] 15 patients had a single ONJ lesion (4A) and 9 patients had multiple lesions (4B) or a “multifocal” lesion (Table 2). Six patients interrupted the treatment with O3 gas application for disease progression (five patients) and for fear of an experimental ther

• br Materials and methods br Results

  2019-06-13

  

  Materials and methods Results Discussion Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most common type of primary bone malignancy [20]. Over the past few decades, the introduction of combinatorial chemotherapy has improved the 5-year overall survival rate of

• br Outstanding questions br Conflict of interest br

  2019-06-13

  

  Outstanding questions Conflict of interest Acknowledgments This work was supported by the Dutch Cancer SocietyUL2015-7599 KWF (EZ). Platelets and cancer metastasis Blood platelets play a primary role in wound healing and hemostasis. Since the first observation made (on himself) by the s

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